USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P23381 USC-OGP 2-DE database:  P23381 P23381 General information about the entry View entry in simple text format Entry name SYWC_HUMAN Primary accession number P23381 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS;. Gene name Name=WARS Synonyms=IFI53, WRS Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0344: pI=5.80; Mw=54833 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0658: pI=5.80; Mw=53924 SPOT OGP-0665: pI=5.76; Mw=51951 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1152: pI=6.04; Mw=54840 Cross-references UniProtKB/Swiss-Prot P23381; SYWC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SYWC_HUMAN Primary accession number P23381 Secondary accession number(s) A6NGN1 A6NID3 P78535 Q502Y0 Q53XB6 Q9UDI5 Q9UDL3 Sequence was last modified on  December 1, 1992 (version 2) Annotations were last modified on  March 15, 2017 (version 176) Name and origin of the protein Description RecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS; Gene name Name=WARS Synonyms=IFI53, WRS Encoded on Name=WARS; Synonyms=IFI53, WRS Keywords 3D-structure; Alternative splicing; Aminoacyl-tRNA synthetase; Angiogenesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M77804; AAA67324.1; -; mRNA EMBL X59892; CAA42545.1; -; mRNA EMBL M61715; AAA61298.1; -; mRNA EMBL X62570; CAA44450.1; -; mRNA EMBL BX248006; CAD62335.1; -; mRNA EMBL AK056100; BAG51626.1; -; mRNA EMBL AK291141; BAF83830.1; -; mRNA EMBL AL157871; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471061; EAW81700.1; -; Genomic_DNA EMBL BC017489; AAH17489.1; -; mRNA EMBL BC095453; AAH95453.1; -; mRNA EMBL S82905; AAB39381.1; -; Genomic_DNA EMBL X67920; CAB94198.1; -; Genomic_DNA EMBL X67921; CAB94198.1; JOINED; Genomic_DNA EMBL X67922; CAB94198.1; JOINED; Genomic_DNA EMBL X67923; CAB94199.1; -; Genomic_DNA EMBL X67924; CAB94199.1; JOINED; Genomic_DNA EMBL X67925; CAB94199.1; JOINED; Genomic_DNA EMBL X67926; CAB94199.1; JOINED; Genomic_DNA EMBL X67927; CAB94199.1; JOINED; Genomic_DNA EMBL X67928; CAB94199.1; JOINED; Genomic_DNA CCDS CCDS9960.1; -. [P23381-1]; . CCDS CCDS9961.1; -. [P23381-2]; . PIR A41633; A41706; . RefSeq NP_004175.2; NM_004184.3. [P23381-1]; . RefSeq NP_776049.1; NM_173701.1. [P23381-1]; . RefSeq NP_998810.1; NM_213645.1. [P23381-2]; . RefSeq NP_998811.1; NM_213646.1. [P23381-2]; . RefSeq XP_005268101.1; XM_005268044.3. [P23381-1]; . RefSeq XP_006720312.1; XM_006720249.3. [P23381-1]; . RefSeq XP_011535435.1; XM_011537133.2. [P23381-1]; . RefSeq XP_011535437.1; XM_011537135.2. [P23381-1]; . RefSeq XP_011535438.1; XM_011537136.2. [P23381-2]; . RefSeq XP_016877116.1; XM_017021627.1. [P23381-1]; . RefSeq XP_016877117.1; XM_017021628.1. [P23381-1]; . RefSeq XP_016877118.1; XM_017021629.1. [P23381-1]; . UniGene Hs.497599; -; . PDB 1O5T; X-ray; 2.50 A; A=94-471 PDB 1R6T; X-ray; 2.10 A; A/B=1-466 PDB 1R6U; X-ray; 2.00 A; A/B=48-471 PDB 1ULH; X-ray; 2.31 A; A/B=82-471 PDB 2AKE; X-ray; 3.10 A; A=94-471 PDB 2AZX; X-ray; 2.80 A; A/B=1-471 PDB 2DR2; X-ray; 3.00 A; A=94-471 PDB 2QUH; X-ray; 2.40 A; A/B=1-471 PDB 2QUI; X-ray; 2.40 A; A/B=1-471 PDB 2QUJ; X-ray; 2.42 A; A/B=1-471 PDB 2QUK; X-ray; 2.80 A; A=1-471 PDBsum 1O5T; -; . PDBsum 1R6T; -; . PDBsum 1R6U; -; . PDBsum 1ULH; -; . PDBsum 2AKE; -; . PDBsum 2AZX; -; . PDBsum 2DR2; -; . PDBsum 2QUH; -; . PDBsum 2QUI; -; . PDBsum 2QUJ; -; . PDBsum 2QUK; -; . ProteinModelPortal P23381; -; . SMR P23381; -; . BioGrid 113292; 60; . DIP DIP-29493N; -; . IntAct P23381; 8; . MINT MINT-1408962; -; . STRING 9606.ENSP00000347495; -; . DrugBank DB00150; L-Tryptophan; . DrugBank DB04537; L-Tryptophanamide; . DrugBank DB01831; Tryptophanyl-5'amp; . MoonProt P23381; -; . iPTMnet P23381; -; . PhosphoSitePlus P23381; -; . SwissPalm P23381; -; . BioMuta WARS; -; . DMDM 135191; -; . OGP P23381; -; . EPD P23381; -; . MaxQB P23381; -; . PaxDb P23381; -; . PeptideAtlas P23381; -; . PRIDE P23381; -; . Ensembl ENST00000344102; ENSP00000339485; ENSG00000140105. [P23381-2]; . Ensembl ENST00000355338; ENSP00000347495; ENSG00000140105. [P23381-1]; . Ensembl ENST00000358655; ENSP00000351481; ENSG00000140105. [P23381-2]; . Ensembl ENST00000392882; ENSP00000376620; ENSG00000140105. [P23381-1]; . Ensembl ENST00000556645; ENSP00000451887; ENSG00000140105. [P23381-2]; . Ensembl ENST00000557135; ENSP00000451460; ENSG00000140105. [P23381-1]; . GeneID 7453; -; . KEGG hsa:7453; -; . UCSC uc001yhg.3; human. [P23381-1]; . CTD 7453; -; . DisGeNET 7453; -; . GeneCards WARS; -; . HGNC HGNC:12729; WARS; . HPA HPA005573; -; . HPA HPA018944; -; . MIM 191050; gene; . neXtProt NX_P23381; -; . OpenTargets ENSG00000140105; -; . PharmGKB PA37340; -; . eggNOG KOG2145; Eukaryota; . eggNOG COG0180; LUCA; . GeneTree ENSGT00390000000666; -; . HOVERGEN HBG002325; -; . InParanoid P23381; -; . KO K01867; -; . OMA FFFSHRD; -; . OrthoDB EOG091G09U9; -; . PhylomeDB P23381; -; . TreeFam TF105669; -; . BRENDA 6.1.1.2; 2681; . Reactome R-HSA-379716; Cytosolic tRNA aminoacylation; . ChiTaRS WARS; human; . EvolutionaryTrace P23381; -; . GeneWiki WARS_(gene); -; . GenomeRNAi 7453; -; . PRO PR:P23381; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000140105; -; . CleanEx HS_WARS; -; . ExpressionAtlas P23381; baseline and differential; . Genevisible P23381; HS; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004830; F:tryptophan-tRNA ligase activity; NAS:UniProtKB; . GO GO:0001525; P:angiogenesis; IEA:UniProtKB-KW; . GO GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc; . GO GO:0045765; P:regulation of angiogenesis; IDA:UniProtKB; . GO GO:0006412; P:translation; TAS:ProtInc; . GO GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; . GO GO:0006436; P:tryptophanyl-tRNA aminoacylation; NAS:UniProtKB; . CDD cd00806; TrpRS_core; 1; . Gene3D 1.10.287.10; -; 1; . Gene3D 3.40.50.620; -; 1; . InterPro IPR001412; aa-tRNA-synth_I_CS; . InterPro IPR002305; aa-tRNA-synth_Ic; . InterPro IPR014729; Rossmann-like_a/b/a_fold; . InterPro IPR009068; S15_NS1_RNA-bd; . InterPro IPR002306; Trp-tRNA-ligase; . InterPro IPR000738; WHEP-TRS_dom; . Pfam PF00579; tRNA-synt_1b; 1; . Pfam PF00458; WHEP-TRS; 1; . PRINTS PR01039; TRNASYNTHTRP; . SMART SM00991; WHEP-TRS; 1; . SUPFAM SSF47060; SSF47060; 1; . TIGRFAMs TIGR00233; trpS; 1; . PROSITE PS00178; AA_TRNA_LIGASE_I; 1; . PROSITE PS00762; WHEP_TRS_1; 1; . PROSITE PS51185; WHEP_TRS_2; 1; .

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